Tsugafolin ke flavonoid, mofuta oa polyphenol ea lijo e fumanoang ka bongata limela tse 'maloa, ho kenyelletsa le li-conifers tse itseng, tse kang kedare ea Japane (Cryptomeria japonica), e melang mofuteng oa Tsuga. Liphuputso tse fetileng li bontšitse hore flavonoids e ka ba le melemo ea bophelo bo botle, ho akarelletsa le anti-inflammatory, antioxidant, le liphello tsa anticancer.
E le ho hlahloba matla a Tsugafolin a khahlanong le kankere, bafuputsi ba ile ba arola motsoako makhasi a Tsuga sieboldii, sefate sa Japane se lulang se le setala. Ka mor'a moo, ba ile ba hlahloba liphello tsa motsoako ho lisele tse 'maloa tsa kankere ea batho, ho akarelletsa le kankere ea matšoafo, kankere ea sebete, mofetše oa mala le mofetše oa matsoele. Liphello li bontšitse hore Tsugafolin e na le cytotoxicity e matla, kapa bokhoni ba ho bolaea lisele, khahlanong le lisele tsena tsa mofetše, tse nang le litekanyetso tsa IC50 ho tloha ho 0.8 ho ea ho 16.9 μM.
Liteko tse ling li senotse hore Tsugafolin e hlahisitse apoptosis, kapa lefu la lisele tse hlophisitsoeng, liseleng tsa mofetše, hammoho le ho falla ha lisele le tlhaselo e thibetsoeng, tseo ka bobeli e leng lits'ebetso tsa bohlokoa metastase ea mofetše. Ho feta moo, Tsugafolin e fumanoe e hatella polelo ea liprotheine tse fapaneng tse amehang litseleng tsa matšoao a mofetše, joalo ka AKT, ERK, le STAT3.
Ho sibolloa ha Tsugafolin e le motsoako oa tlhaho oa anticancer ho ka bula mekhoa e mecha ea kalafo le thibelo ea mofetše. Ho fapana le lithethefatsi tsa maiketsetso, metsoako ea tlhaho e na le molemo oa ho sireletseha ka kakaretso le ho mamelloa hantle ke 'mele oa motho, hape e ka fana ka litempele tse ncha tsa moralo bakeng sa moralo oa lithethefatsi. Leha ho le joalo, ho hlokahala lipatlisiso tse ling pele Tsugafolin e ka ntlafatsoa ho ba setlhare sa bongaka sa kalafo ea mofetše.
